According to the Centers for Disease Control and Prevention (CDC), the 2017-2018 flu season appears particularly virulent. Influenza activity increased significantly in December, with influenza A(H3N2) viruses predominating, and in a December 27 notice, the agency noted that “In the past, A(H3N2) virus-predominant influenza seasons have been associated with more hospitalizations and deaths in persons aged 65 years and older and young children …”1

While influenza can indeed be deadly in rare cases, what most health experts fail to tell you is that these deaths are typically the result of secondary infections, not the flu virus itself. Importantly, research has highlighted the link between influenza and severe sepsis — a progressive disease process initiated by an aggressive, dysfunctional immune response to an infection in the bloodstream (which is why it’s sometimes referred to as blood poisoning).

Symptoms of sepsis are often overlooked, even by health professionals, and without prompt treatment, the condition can be deadly. Unfortunately, conventional treatments often fail, and most hospitals have yet to embrace the use of intravenous (IV) vitamin C, hydrocortisone and thiamine,2 which has been shown to reduce sepsis mortality from 40 to a mere 8.5 percent.3,4

How Influenza May Cause Lethal Sepsis

https://www.youtube.com/watch?v=69s6ezhwTWQ

 

According to researchers, “Severe sepsis is traditionally associated with bacterial diseases … However, viruses are becoming a growing cause of severe sepsis worldwide.” As noted in the video above, some sepsis symptoms also resemble influenza, which can lead to tragedy. The video offers guidelines on how to tell the difference between the two.

Sepsis, without doubt, requires immediate medical attention, whereas most people will successfully recover from the flu with a few days to a week of bedrest and fluids. Just how influenza can lead to sepsis is a somewhat complex affair, described as follows:5 

“Regardless of the etiologic agent, the inflammatory response is highly interconnected with infection. In the initial response to an infection, severe sepsis is characterized by a pro-inflammatory state, while a progression to an anti-inflammatory state develops and favors secondary infections …

In the predominant pro-inflammatory state, Th1 cells activated by microorganisms increase transcription of pro-inflammatory cytokines such as tumor necrosis factor (TNF-α), interferon-γ (INF-γ), and interleukin-2 (IL-2).

[C]ytokines … released from endothelial cells and subsequently from macrophages can induce lymphocyte activation and infiltration at the sites of infection and will exert direct antiviral effects. Subsequently, with the shift toward an anti-inflammatory state, activated Th2 cells secrete interleukin-4 (IL-4) and interleukin-10 (IL-10).

In certain situations, T cells can become anergic, failing to proliferate and produce cytokines. Type I IFN has a potent anti-influenza virus activity; it induces transcription of several interferon stimulated genes, which in turn restrict viral replication. However, influenza virus developed several mechanisms to evade IFN response …

Viral infections such as the influenza virus can also trigger deregulation of the innate immune system with excessive cytokines release and potential harmful consequences. An abnormal immune response to influenza can lead to endothelial damage … deregulation of coagulation, and the consequent alteration of microvascular permeability, tissue edema, and shock.”

Signs and Symptoms of Sepsis

Common signs and symptoms of sepsis to watch out for include:6

• A high fever

• Inability to keep fluids down

• Rapid heartbeat; rapid, shallow breathing and/or shortness of breath

• Lethargy and/or confusion

• Slurred speech, often resembling intoxication

Should a few or all of these be present, seek immediate medical attention to rule out sepsis. Also inform the medical staff that you suspect sepsis, as time is of the essence when it comes to treatment. As noted in the featured video, hydration is of utmost importance, as much of the damage caused by sepsis begins with fluid loss.