‘Safe’ BPA Substitutes Tied to Fertility Damage, Fetal Harm, and Generational Effects, Review Finds
February 18, 2026 | Source: U.S. Right to Know | by Pamela Ferdinand
Chemicals increasingly used to replace the toxic plastic additive bisphenol A (BPA) may disrupt fertility, fetal development, and reproductive health through many of the same biological mechanisms, according to a narrative review of human, animal and laboratory studies.
Concerns about BPA have led some manufacturers to phase it out and replace it with structurally similar compounds, most commonly bisphenol S (BPS), bisphenol F (BPF) and bisphenol AF (BPAF). While BPA exposure has declined, BPS and BPF use is rising, especially in North America and Asia.
The review, published this month [February 2026] in Archives of Medical Research, found that these BPA substitutes—widely used in plastics, processed food and food packaging, children’s toys, and paper receipts—can interfere with the same hormone systems and gene-regulation pathways that control reproductive development in both males and females.