The novel coronavirus arrived in an Indiana farm town mid-planting season and took root faster than the fields of seed corn, infecting hundreds and killing dozens. It tore through a pork processing plant and spread outward in a desolate stretch of the Oklahoma Panhandle. And in Colorado’s sparsely populated eastern plains, the virus erupted in a nursing home and a pair of factories, burning through the crowded quarters of immigrant workers and a vulnerable elderly population.

As the death toll nears 100,000, the disease caused by the virus has made a fundamental shift in who it touches and where it reaches in America, according to a Washington Post analysis of case data and interviews with public health professionals in several states. The pandemic that first struck in major metropolises is now increasingly finding its front line in the country’s rural areas; counties with acres of farmland, cramped meatpacking plants, out-of-the-way prisons and few hospital beds.