Glyphosate Exposure Linked to Behavioral and Gut Health Concerns in New Studies

(Beyond Pesticides, November 15, 2023) A study previously published in the Federation of American Societies for Experimental Biology (FASEB) is drawing renewed attention to the gut microbiome in the scientific community. The study, involving a team including Demetrio Sierra-Mercado, PhD, of the University of Puerto Rico School of Medicine, initially established a link between glyphosate exposure and increased anxiety and fear-related behavior in rats. Glyphosate, a widely-used herbicide, has been detected in trace amounts in fruits, vegetables, grains, and other food and beverages, according to the U.S. Environmental Protection Agency (EPA). Originally deemed safe for humans due to the way it interacts with the shikimic acid pathway—a metabolic route that is absent in humans—glyphosate’s indirect effects on human health are now under scrutiny as the research linking it to anxiety-like behavior grows.

Dr. Sierra-Mercado’s team is expanding on his previous research to take a closer look at the compound’s potential disruption of the gut microbiome, which plays a pivotal role in regulating both physical and mental health.