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Editor’s Note: The following is an excerpt from Acid Dreams author Martin A. Lee’s new book Smoke Signals: A Social History of Marijuana — Medical, Recreational, and Scientific  (Simon and Schuster, 2012):

Peer-reviewed scientific studies in several countries show THC and other compounds found only in marijuana are effective not only for cancer symptom management (pain, nausea, loss of appetite, fatigue, and so on), but they confer a direct antitumoral effect as well.

Animal experiments conducted by Manuel Guzman at Madrid’s Complutense University in the late 1990s revealed that a synthetic cannabinoid injected directly into a malignant brain tumor could eradicate it. Reported in Nature Medicine , this remarkable finding prompted additional studies in Spain and elsewhere that confirmed the anticancer properties of marijuana-derived compounds. Guzman’s team administered pure THC via a catheter into the tumors of nine hospitalized patients with glioblastoma (an aggressive form of brain cancer) who had failed to respond to standard therapies. This was the first clinical trial assessing the antitumoral action of cannabinoids on human beings, and the results, published in the British Journal of Cancer , were very promising. THC treatment was associated with significantly reduced tumor cell proliferation in all test subjects.