OIL CITY, Pa. — In 1859, Edwin Drake drilled the world’s first commercial oil well in this rural corner of northwestern Pennsylvania, helping kindle the petroleum age. But over time, most of the easy oil was extracted and the big companies moved on, leaving rusty oil wells and shut-down refineries in their wake.

Sky-high crude prices have now sparked what some locals see as the storied area’s last hurrah. Hoping for a final gulp of black gold, old-timers and upstarts are going after what’s left in the world’s original oil patch with drill bits, …

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