Are These the 19 Most Important Supplements To Take?

March 25, 2023 | Source: LewRockwell.com | by Dr. Joseph Mercola

While dietary supplements cannot take the place of a healthy lifestyle, they can be used strategically to boost your health, especially in cases of deficiency. In the U.S., 57.6% of adults aged 20 and over use supplements, with multivitamins, vitamin D and omega-3 fats representing the top three.1  Another survey put the percentage of Americans using supplements at 86%.2

So, it’s safe to say that many people are interested in taking control of their health with the support of supplemental vitamins, minerals and other compounds. But, when it comes to supplements, more isn’t always better.

To ensure you’re using only supplements you need — avoiding wasting your money while maintaining your body’s balance — I recommend using dietary interventions first. Next, work with a holistic health care practitioner who can guide you on which supplements your body truly needs.

19 Supplements I Consider Essential

The best supplements for you depend on your age, health status and health goals. If having a practitioner guide you isn’t possible, essential supplements may be next on your list — and I’ve compiled the list in rank order of what I believe to be the most important ones.

Some of the most important individual variables you need to consider would be if you are plant-based or choose to eat animal products. While many plant-based diets are fundamentally healthy, they do lack some vital nutrients, like vitamin B12, retinol, vitamin K2, carnosine, carnitine, collagen and choline. If you are plant-based, you will certainly want to consider adding these to your regimen.

1. Molecular Hydrogen (H2)

Molecular hydrogen acts as a selective antioxidant, meaning it doesn’t indiscriminately suppress free radicals. Rather, it’s unique in that it helps your body make its own endogenous antioxidants. This is important because excessive use of antioxidants can be counterproductive, while molecular hydrogen serves as a redox regulator.

The H2 molecule is the smallest in the universe, which allows it to diffuse through all cell membranes, including the blood-brain barrier and subcellular compartments, and into the mitochondria. According to Tyler LeBaron, Ph.D., it’s been shown to have therapeutic benefits in more than 170 different animal disease models.3  While there’s no risk of overdosing on molecular hydrogen, intermittent exposure produces the best results.

2. Vitamin D

Vitamin D has multiple actions on the immune system, including enhancing the production of antimicrobial peptides by immune cells, reducing damaging pro-inflammatory cytokines, and promoting the expression of anti-inflammatory cytokines.4

A recent study found giving vitamin D to people with COVID-19 cut risk of death from SARS-CoV-2 by 51% and reduced risk of admission to the intensive care unit (ICU) by 72%.5,6 Vitamin D also plays a role in heart disease, as it improves circulation and may be beneficial for high blood pressure. In addition, due to its effects on endothelial function, vitamin D may also help improve or prevent heart failure, heart attack, vasculopathy, stroke and diabetes.7

Ideally, optimize your vitamin D levels via sensible sun exposure, as there are many benefits to sun exposure even aside from vitamin D, such as increasing mitochondrial melatonin by near infrared (IR) exposure.

My vitamin D level is typically between 80 and 100 and I haven’t taken any vitamin D supplements so you can get your levels high if you are disciplined about your sun exposure. Just be sure to make sure you are eating a very low linoleic acid (LA) diet as it is excessive omega-6 fats that virtually everyone consumes, that cause sun-induced skin cancers.

However, if getting healthy sun exposure simply isn’t an option for you due to your location or lifestyle, daily vitamin D3 supplementation of 8,000 to 10,000 units is likely needed to reach a vitamin D level of 60 to 80 ng/mL.

Data from GrassrootsHealth’s D*Action studies suggest the optimal level for health and disease prevention is between 60 ng/mL and 80 ng/mL, while the cutoff for sufficiency appears to be around 40 ng/mL. In Europe, the measurements you’re looking for are 150 to 200 nmol/L and 100 nmol/L respectively.

The only way to gauge whether you might need to supplement, and how much to take, however, is to get your level tested, ideally twice a year — in the early spring and early fall — when your level is at its low point and peak, respectively. Make sure that your supplemental vitamin D intake is balanced with other nutrients, including vitamin K2 (to avoid complications associated with excessive calcification in your arteries) and magnesium.

3. Niacinamide

NAD+ (nicotinamide adenine dinucleotide) is one of the most important biomolecules in your body. It’s involved in the conversion of food to energy, maintaining DNA integrity and ensuring proper cell function. Together, these functions help protect against or delay aging and virtually all chronic disease.

NAD+ also acts as fuel for longevity proteins called sirtuins. Sadly, NAD levels dramatically decline with age, contributing to aging and chronic disease states. NAD is also used up by DNA repair enzymes and enzymes involved in inflammation and immunity, such that chronic inflammation, or acute illness in old age, can rapidly result in depletion.

To restore NAD_, you need to fix the root cause for NAD+ depletion, which primarily involves addressing the decline in the NAD salvage pathway. By increasing enzymes in that pathway, which decline with age, your body can recycle NAD_ like it did naturally when it was younger. For more information, please review my fantastic interview with molecular biologist Nichola Conlon, Ph.D.

In addition to optimizing NAD+ levels, it also blocks lipolysis which is important if you are the more than 99% of the population that have elevated linoleic acid (LA) levels. Reducing the release of LA from your tissues will lower the amount of oxidative stress in in your body.