4 New Pesticides Ignite Debate Over PFAS Definition

July 14, 2025 | Source: Chemical & Engineering News | by Britt E. Erickson

The US Environmental Protection Agency is doubling down on efforts to decrease a backlog of new pesticide active ingredients waiting for EPA approval to enter the marketplace. Since April, the agency has proposed registering four of them—cyclobutrifluramdiflufenicanisocycloseram, and trifludimoxazin.

All four pesticides contain a fully fluorinated methyl or methylene group, raising concerns that they will persist in soil and water for many years. Environmental groups argue that the chemicals are per- and polyfluoroalkyl substances (PFAS) under the definition recommended by the Organisation for Economic Co-operation and Development (OECD) in 2021. PFAS are notoriously difficult to remove from the environment, and some of them are toxic at extremely low levels.